Improved Diagnosis of Systemic Sclerosis Using Nailfold Capillary Flow
نویسندگان
چکیده
Nailfold capillaroscopy (NC) allows non-invasive imaging of systemic sclerosis (SSc) related microvascular disease. We have developed a state-of-theart NC system that enables fast, panoramic imaging of the whole nailfold at highmagnification, and incorporates novel software to make fully automated estimates of capillary structure and blood flow velocity. We present the first results of a study in which 50 patients with SSc, 12 with primary Raynauds phenomenon (PRP) and 50 healthy controls (HC) were imaged using the new system, and show that a combined model of capillary measurements strongly separates SSc from HC/PRP (ROC Az=0.93). Including capillary flow improves model performance, suggesting flow provides complementary information to capillary structure for diagnosing SSc.
منابع مشابه
Usefulness of nailfold videocapillaroscopy for systemic sclerosis
Systemic sclerosis is a complex disease that involves "autoimmunity," "inflammation," "fibrosis," and "vasculopathy." Microvascular damage and dysfunction particularly represent the earliest morphological and functional markers of systemic sclerosis. These morphological changes and progressions can be detected by nailfold videocapillaroscopy (NVC). In 2013, the American College of Rheumatology ...
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